Access to genetic data after quality control by the MoBaPsychGen pipeline v.1
For researchers in MoBa: MoBaPsychGen pipeline v.1
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The PsychGen project has performed a comprehensive quality control of the genetic data in MoBa. This work is ongoing, led by Elizabeth Corfield and a collaboration between the Norwegian Institute of Public Health and NORMENT. The first version of quality-controlled data was ready for use in March 2022. These data are stored on TSD p471.
It is possible to access this data if the following two prerequisites are in place:
- The project receiving data must have been granted access and approval for using the genotype data from MoBa Genetics (TSD p299) both from MoBa and from REK.
- For more information on how to access genetic data from MoBa please follow this link: https://www.fhi.no/en/studies/moba/for-forskere-artikler/research-and-data-access/
- PsychGen and the project that is to receive data must both have approval from REK regarding the sharing of quality-assured versions of the genotype data across these two projects. The quality-controlled files are products of the genotype data to which both projects already have access, via MoBa Genetics. No project-specific data will be shared.
When all approvals are in place, the project administrator in PsychGen sends a request to TSD to create a folder that allows one-way sharing with the project receiving data (this project has read-only access) and attaches the REK approval for sharing. The sharing will follow established data processing routines within TSD, and the data never leave TSD.
All researchers who use data from MoBaPsychGen pipeline v.1 must credit the researchers/projects that did the quality control work by citing the MoBaPsychGen pipeline paper:
The Norwegian Mother, Father, and Child cohort study (MoBa) genotyping data resource: MoBaPsychGen pipeline v.1Elizabeth C. Corfield, Oleksandr Frei, Alexey A. Shadrin, Zillur Rahman, Aihua Lin, Lavinia Athanasiu, Bayram Cevdet Akdeniz, Laurie Hannigan, Robyn E. Wootton, Chloe Austerberry, Amanda Hughes, Martin Tesli, Lars T. Westlye, Hreinn Stefánsson, Kári Stefánsson, Pål R. Njølstad, Per Magnus, Neil M. Davies, Vivek Appadurai, Gibran Hemani, Eivind Hovig, Tetyana Zayats, Helga Ask, Ted Reichborn-Kjennerud, Ole A. Andreassen, Alexandra HavdahlbioRxiv 2022.06.23.496289; doi: https://doi.org/10.1101/2022.06.23.496289
Find more information
- Full details of the quality control are described in the MoBaPsychGen pipeline paper.
- MoBaPsychGen pipeline code
- A companion R package, genotools, can be installed to assist users.
Do you already have access to MoBa genetic data and want access to the quality controlled genetic data processed via the MoBaPsychGen pipeline v.1? Contact PsychGen project coordinator Stian Valand
