Methods and tools for assessing chemical exposure in humans: protocol for a systematic scoping review

Summary

The project ‘Ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment’ (ONTOX) under the EU programme Horizon 2020 is running from 01.05.21 to 30.04.26 and is coordinated by Vrije Universiteit, Brussel, Belgium (project website, URL: https://ontox-project.eu/project/).

The vision of ONTOX is to provide a functional and sustainable solution for advancing human risk assessment of chemicals without the use of animals in line with the principles of 21st century toxicity testing and next generation risk assessment. ONTOX will perform exposure assessment on selected chemicals. Preferably existing dietary, dermal and inhalation exposure methods and/or tools will be used. In order to have the best selection of tools available, we will conduct this scoping review to get an overview over publicly available exposure methods/tools.

We will assess the advantages and disadvantages of the different methods that we identify.