Sammenhengen mellom overvekt, vitamin D og leptin og føflekkreft: forekomst, overlevelse og risiko for ny kreftsykdom etter føflekkreft

Sammendrag

Norway has high incidence and mortality rates of cutaneous malignant melanoma (CMM), and lower survival rate compared to other countries. Exposure to ultraviolet radiation (UVR) causes CMM, but also induces synthesis of vitamin D (VD). Low VD levels may increase the risk of and worsen the survival of cancers, but little is known for CMM. A diagnosis of CMM increases the risk of a second cancer, in particular the risk of lymphoma, which has led to a hypothesis about UVR and/or vitamin D as shared etiologic factors. Obesity is linked to low VD, high leptin levels and to CMM risk. We aim to study whether BMI, serum VD and leptin influence risk and survival of CMM, risk of a second primary cancer after CMM, and how lymphoma risk is related to vitamin D. The project will be based on measured BMI (Norwegian health surveys), serum VD and leptin (Janus Serum Bank), cancer data (the Cancer Registry), death data (Cause of Death Registry) and proxies of UVR exposure (Statistics Norway).