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Health Studies 1974-2013

Health studies have been conducted in several regions around Norway.

The Hordaland Health Study - HUSK

The Hordaland Health Study ’97-’99 (HUSK) was conducted during 1997-99. The study population included all individuals in Hordaland County born 1953-57 (29,400).

A total of 8,598 men and 9,983 women participated in the study, yielding a participation rate of 57% for men and 70% for women. The study also included 2,291 men and 2,558 women born 1950-51 and 1,868 men and 2,470 women born 1925-27 and who had participated in an earlier study in 1992-93 (the Hordaland Homocysteine Study, referred to as the Homocysteine cohort). Participation rates in these groups were 73%, 81%, 79%, and 76%, respectively.

In addition to the standard measurements of CONOR, baseline measurements included serum creatinine. Self-administered questionnaires included open-ended questions regarding occupation and industrial affiliation as well as use of medicinal and dietary supplements.

HUSK includes a total of 1.5 - 2 ml full blood stored in two vials from 25,583 participants. In addition, there is serum from 23,151 participants. For the Homocysteine cohort there is plasma from 7,053 persons. In addition there is stored blood from approximately 18,000 persons who participated in the Homocysteine study in 1992/93.

Ancillary projects addressed psychiatric disorders, psychosocial factors, social support and social stress while several projects were related to occupation, health-related quality of life, as well as standard questionnaires on sleeping behaviour. In addition to the survey components included for the youngest cohort, the homocysteine cohort included ancillary studies on plasma homocysteine, serum measurements of B-vitamins and related genetic polymorphisms (methylene tetra hydroxy folate reductase, factor V Leiden, apo E and folate reductase), a quantitative food frequency questionnaire, measurements of bone mineral density (total body and hip) and spirometry. The oldest cohort (born 1925-27) also participated in a 30-minute interview on cognitive function.

The OPPHED Health Study

The population-based OPPHED (Oppland and Hedmark) Health Study was conducted in 2000-2001. All men and women in selected age groups were invited to participate.

The objectives were in principle the same as for the Oslo Health Study.

All men and women in Oppland and Hedmark counties in five different age groups (born in 1925, 1940, 1955, 1960 and 1970) were invited to participate. The OPPHED Health Study participants provided standard blood samples and measurements, and answered the mutual CONOR questionaire that covered the same main topics as for the Oslo Health Study.

In addition to the original invitation, non-responders received two reminders. Of the 22,000 invited, 12,400 individuals (56%) participated in the survey and provided a blood sample. Two 6 ml full blood samples are stored at -80 degrees Celsius. A 2 ml aliquot is reserved for CONOR.

A cohort including all 15- and 16-year olds in Oppland and Hedmark will be asked to complete two questionnaires at school. They will not be invited to the clinical examination and no blood samples will be collected.

The TROFINN Health Study

The population-based TROFINN Health Study (Troms and Finnmark County – except Tromsø) started in 2001 and finished in 2003. The objectives are in principle the same as for the Oslo Health Study.

The TROFINN Study is divided into three parts: the county of Troms except those participating in the 5th Tromsø Study, the county of Finnmark (except the Samii communities) and the Samii Health Study. All men and women in Troms and Finnmark in five different age groups were invited to participate. In Tromsø, this applies to those born in 1926, 1941, 1956, 1961 and 1971, in the rest of Troms and in Finnmark it applies to those born in 1927, 1942, 1957, 1962, 1972. In addition, all who were invited to the previous Finnmark Studies (I-III) will be invited (born 1925-1969).

This part of TROFINN constitutes about 20,000 invited individuals. Additionally, people aged 35-77 years living in areas with special ethnic settling in Troms and Finnmark (23 000) will be invited (the Samii Health Study). The participation in the TROFINN-part of Tromsø was 56%. In addition to the adult cohorts, all 15- and 16-year olds in Troms and Finnmark will complete two questionnaires at school. They will not be invited to the clinical examination, and no blood samples will be collected.

The blood samples containing 6 ml full blood, are stored at –80°C. A 2 ml aliquot is reserved for CONOR. The TROFINN Health Sudy participants provided standard blood samples and measurements, and answered the CONOR-questionnaire that covered the same main topics as mentioned for the Oslo Health Study. The study is not finished.

The Tromsø Health Studies

The Tromsø study is a prospective follow-up study of entire birth cohorts and random samples in the municipality of Tromsø. The surveys were carried out in 1974, 1979/80, 1986/87 and in 1994/95.

The fourth survey was completed in October 1995 and combined for the first time in Norway mass screening with advanced ultrasound technology. A total of 27163 subjects aged 25+ years participated in the basic examination, which was similar to the previous surveys. All persons 55-74 years old and 5-10% samples in the other age groups were asked to return for a more comprehensive examination 4 to 12 weeks later. A total of 6889 subjects attended the second visit, which comprised a number of blood and urine tests, ECG, and ultrasonographic examination of the right carotid artery, ultrasonography of abdominal aorta, echocardiography of the heart, and forearm bone mineral densitometry (BMD). In addition to the Phase II participants, all women aged 50-54 years were invited; thus the total sample for BMD comprised 7948 subjects.

In 2001, 10429 subjects were invited to the last survey, which was completed in December 2001. All subject who participated in the comprehensive examination in 1994-95 and who were still living in Tromsø (7071 subjects), were invited, and 85% participated.